A Meta–Analysis and Systematic Review to Determine the Pregnancy Outcomes in Mothers with inactive Hepatitis B Carrier
Keywords:Inactive hepatitis B, Pregnancy, adverse effects on pregnancy
Objective: Our goal was to investigate whether asymptomatic maternal hepatitis B
(HB) infection affects early membrane rupture (PROM), fetal death, preeclampsia,
eclampsia, gestational hypertension, or bleeding before delivery.
Materials and Methods: This study was conducted in the Department of Community Medicine and Obstetrics and Gynecology department, KEMU Lahore for one-year duration
from May 2017 to April 2018. The electronic literature surveys were conducted
using gray literature studies (e.g. conference papers and final reports). (Technicians) and scanned reference lists of attached studies and systematically related studies.
We study statistical heterogeneity using statistical tests I2 and tau square (Tau2).
Results: 18 studies included. Early membrane ruptures (PROM), fetal death,
preeclampsia, eclampsia, gestational hypertension and prenatal bleeding were
obtained in this study. The results showed no significant relationship between
inactive HB and these complications during pregnancy. Small amounts of P and
chi-square and large amounts of I2 have revealed heterogeneity, which we are
trying to modify using statistical methods such as subgroup analysis in this chapter.
Conclusion: Inactive HB infection did not increase the risk of adverse effects in
this study. In addition, well-designed tests should be performed to confirm the