A Meta–Analysis and Systematic Review to Determine the Pregnancy Outcomes in Mothers with inactive Hepatitis B Carrier

Abstract

Objective: Our goal was to investigate whether asymptomatic maternal hepatitis B

(HB) infection affects early membrane rupture (PROM), fetal death, preeclampsia,

eclampsia, gestational hypertension, or bleeding before delivery.

Materials and Methods: This study was conducted in the Department of Community Medicine and Obstetrics and Gynecology department, KEMU Lahore for one-year duration

from May 2017 to April 2018. The electronic literature surveys were conducted

using gray literature studies (e.g. conference papers and final reports). (Technicians) and scanned reference lists of attached studies and systematically related studies.

We study statistical heterogeneity using statistical tests I2 and tau square (Tau2).

Results: 18 studies included. Early membrane ruptures (PROM), fetal death,

preeclampsia, eclampsia, gestational hypertension and prenatal bleeding were

obtained in this study. The results showed no significant relationship between

inactive HB and these complications during pregnancy. Small amounts of P and

chi-square and large amounts of I2 have revealed heterogeneity, which we are

trying to modify using statistical methods such as subgroup analysis in this chapter.

Conclusion: Inactive HB infection did not increase the risk of adverse effects in

this study. In addition, well-designed tests should be performed to confirm the

results.