Effect of Intravenous Phloroglucinol Injections upon duration of Active First Stage of Labor
Intravenous Phloroglucinol Effect on First Stage of Labor
Keywords:First Stage of Labor, Labor duration, Pakistan, Phloroglucinol
Objective: In our part of the world poverty and illiteracy has adversely affected our core objective of pregnancy i.e. healthy mother and healthy child. Exploring the role of a routinely used drug in reducing the duration of labor could be a breakthrough. Present study was planned accordingly to evaluate the effect of phloroglucinol (PHL).
Materials and Methods: It was a Randomized controlled trial conducted at Department of Obstetrics & Gynecology, Combined Military Hospital, Bahawalpur from January 2019 to June 2019. This study included 60 cases of age 18 to 40 years, having singleton pregnancy and in active first stage of uncomplicated labor. Patients with history of multiple pregnancies, obstetrical and surgical complications and cardiorespiratory diseases were excluded. The cases were placed randomly into Group A & Group B and given intravenous PHL and a placebo respectively. After this, duration of the first stage of labor was recorded in minutes from when there was 3-4 cm cervical dilatation with regular uterine contractions to complete cervical dilation i.e. 10 cm and descent of the presenting fetal part.
Results: Mean duration of active first stage of labor in experimental group A (230.20 ± 52.96 minutes) was significantly higher than that of control group B (345.30 ± 50.57 minutes).
Conclusion: This study concluded that intravenous PHL has efficiently reduced the duration of active first stage of labor in these randomly selected nulliparous and multiparous women. PHL is a useful drug serving the purpose of a spasmolytic, analgesic and labor augmentation at the same time.
Medscape, Drugs & Diseases, Obstetrics & Gynecology. [Internet]. [Milton (MD)]. Normal Labor and delivery. 2019. [cited 15th March 2020]. Available from: https://emedicine.medscape.com/article/260036-overview
Caughey AB, Cahill AG, Guise JM, Rouse DJ. Safe prevention of the primary cesarean delivery. Am J Obstet Gynecol. 2014;210(3):179-93. Available from: doi:https://doi.org/10.1016/j.ajog.2014.01.026
World Health Organization 2018, WHO recommendations on definitions of the latent and active first stages of labor. Available from: https://extranet.who.int/rhl/topics/preconception-pregnancy-childbirth-and-postpartum-care/care-during-childbirth/care-during-labor-first-stage/who-recommendation-definitions-latent-and-active-first-stages-labor-0/[Accessed 3rd March 2020].
Selin L. Delayed labor-risk factors, use of oxytocin and outcomes. University of Gothenburg. Gothenburg. 2018. Available from: http://hdl.handle.net/2077/56333.
White L, Lee N, Beckmann M. First stage of labor management practices: A survey of Australian obstetric providers. Aus N Z J ObstetGynaecol. 2017;57(3):266-71. Available from: doi:https://doi.org/10.1111/ajo.12510
Sheikh S, Qureshi RN, Raza F, Memon J, Ahmed I, Vidler M, et al. Self-reported maternal morbidity: Results from the community level interventions for pre-eclampsia (CLIP) baseline survey in Sindh, Pakistan. Pregnancy Hypertension. 2019;17(1):113-20. Available from: doi:https://doi.org/10.1016/j.preghy.2019.05.016
Maternal and newborn Health Disparities in Pakistan: Key Facts. UNICEF. Report number: UNI59616/Ramoneda. Available from: https://data.unicef.org/wp-content/uploads/country_profiles/Pakistan/country%20profile_PAK.pdf [Accessed 9th March 2020].
Bugg GJ, Siddiqui F, Thornton JG. Oxytocin versus no treatment or delayed treatment for slow progress in the first stage of spontaneous labor. The Cochrane database of systematic reviews. 2013(6): Cd007123. Available from: doi:https://doi.org/10.1002/14651858.CD007123.pub3
National services for advancing translational sciences. Inxight: Drugs. Available from: https://drugs.ncats.io/drug/DHD7FFG6YS [Accessed 14th March 2020].
Lopes-Costa E, Abreu M, Gargiulo D, Rocha E, Ramos AA. Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells. J Toxicol Environ Health A. 2017;80(13-15):776-87. Available from: doi:https://doi.org/10.1080/15287394.2017.1357297
Tahir S, Liaqat M, Jabeen S, Rasul S. Effectiveness of Phloroglucinol to accelerate labor in Primigravidas at term: Double blind, randomized controlled trial. Pak J Med Health Sci. 2015;9(1):169-72.
Naqvi SB, Haroon Z. Efficacy and safety of drotaverine and phloroglucinol in first stage of labor. Pak J Surg. 2011;27(1):39-43.
Tahira T, Aslam M, Saleem S. Comparison of Phloroglucinol and Drotaverine in Accelerating First Stage of Labor. APMC. 2018;12(4) 247-51. Available from: doi: http://apmcfmu.com/index.php/apmc/article/view/3
Janjua M, Waheed K, Iqbal T, Ejaz S. Efficacy of Phlorogucinol in Comparison to Drotaverine Hydrochloride in Reducing Duration of Active Phase of first Stage of Labor in Primigravidae at Term. J Soc ObstetGynaecol Pak. 2018;8(1):36-40. Available from: doi: http://www.jsogp.net/index.php/jsogp/article/view/126
Ara B, Anwar A, Salam R. Comparison of mean duration of first and second stage of labor in term primigravida with and without phloroglucinol. PJMHS. 2016;10(3):994-7.
Parveen T, Hussain H, Khattak NN. Effects of phloroglucinol on augmentation of labor in primigravida. J Med Sci. 2013;21(3):131-33.
Tchente CN, Nana TN, Tolefac PN, Abanda MH, Angong FTE, Tamambang RF, et al. Effects of phloroglucinol on the active phase of labor (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa. Pan Afr Med J. 2018;30:17. Available from: doi: doi:10.11604/pamj.2018.30.17.14728
Yuan S, Gao F, Xin Z, Guo H, Shi S, Shi L, et al. Comparison of the efficacy and safety of phloroglucinol and magnesium sulfate in the treatment of threatened abortion: A meta-analysis of randomized controlled trials. Medicine. 2019;98(24):e16026. Available from: doi: http://dx.doi.org/10.1097/MD.0000000000016026
Xu A, Li Y, Zhu L, Tian T, Hao J, Zhao J, et al. Inhibition of endometrial fundocervical wave by phloroglucinol and the outcome of in vitro fertilization. Reprod Biol. 2013;13(1):88-91. Available from: doi: https://doi.org/10.1016/j.repbio.2013.01.165
Blanchard C, Pouchain D, Vanderkam P, Perault-Pochat MC, Boussageon R, Vaillant-Roussel H. Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo. Eur J Clin Pharmacol. 2018;74(5):541-8. Available from: doi: https://doi.org/10.1007/s00228-018-2416-6
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