Frequency of restrictive pulmonary function tests in patients with chronic Hepatitis C

Authors

  • shahid Hamid Dubai hospital , alhameed medical center
  • Khalid Medicine, King Edward Medical University Lahore
  • fawad Medicine, King Edward Medical University Lahore
  • Asia Firdous King Edward Medical University Lahore

DOI:

https://doi.org/10.37978/pjsm.v1i4.223

Keywords:

Liver Cirrhosis, Pulmonary fibrosis, Respiratory Function Tests, Hepatitis C

Abstract

Hepatis C infection is a common health problem world wide and is the major cause of chronic liver disease in Pakistan. Common complications of chronic hepatitis c infection are cirrhosis, ascities and hepatocellular carcinoma. Also HCV infection is associated with several extra hepatic manifestations including interstitial lung fibrosis. It has been found that frequency of pulmonary fibrosis is increased in patients with cirrhosis of liver as the stage of cirrhosis advances.This lung fibrosis can cause restrictive pattern of pulmonary function tests. This study was conducted to determine frequency of restrictive pulmonary function in patients with different stages of chronic hepatitis C  infection, based on child pough classification.

Study design

This is descriptive case study

Method

99 patients of age range 20 to 80 year, both males and females having chronic hepatitis C infection and interferon based treatment naïve patients were included from outpatient and inpatient department were selected. Patients were divided into three groups according to child’s criteria i.e. group A, group B, and group C. Pulmonary function tests were performed on patients in all three groups to look for  FEV1/FVC ratio in all patients. FEV1/FVC ratio  more than 80 was considered as restrictive pulmonary function.

Results

Out of 99 patients 32(35%) were found to have restrictive pattern of pulmonary functions

Conclusion

Chronic hepatitis C infection is associated with restrictive pattern of pulmonary function, suggestive of pulmonary fibrosis.

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References

Nadeem MA, Waseem T, Sheikh AM, Grumman N, Irfan K, Hasnain SS. Hepatitis C virus: an alarmingly increasing cause of liver cirrhosis in Pakistan. Pak J Gastroenterol. 2002;16(1):3–8.

Hamid S, Masood M. Frequency of pulmonary fibrosis in patients with cirrhosis of liver. Esculapio. 2008;4(1):21–3.

Anstee Q, Jones D. Hepatology. Davidson’s principles and practice of medicine. 23rd ed. London: Elsevier; 2018. 877–8 p.

Lawrence S, Friedman M. Liver biliary tract and pancreas. In: Current medical diagnosis and treatment. Newyork: McGraw Hill; 2019. p. 697–8.

Demir C, Demir M. Effect of hepatitis C virus infection on the right ventricular functions, pulmonary arterypressure and pulmonary vascular resistance. Int J Clin Exp Med. 2014;7(8):2314.

Zidan M, Daabis R, El Sayed P, Samir S. Prevalence of chronic hepatitis C virus (HCV) infection in patients with idiopathic pulmonary fibrosis. Egypt J Chest Dis Tuberc. 2015;64(4):907–13.

Elhelaly S, Ragab M, Elkomy H, Fathy T. Pulmonary hazards of chronic hepatitis C virus infection treatment with Pegylated interferon and ribavirin vs. untreated patients. Egypt J

Chest Dis Tuberc. 2013;62(2):325–9.

Franciscus A. An overview of extrahepatic manifestations of hepatitis C. HCSP Fact Sheet. 2015;7:1–6.

Viegi G, Fornai E, Ferri C, Di Munno O, Begliomini E, Vitali C, et al. Lung function in essential mixed cryoglobulinemia: a short-term follow-up. Clin Rheumatol. 1989;8(3):331–8.

Weidensaul D, Imam T, Holyst M, King PD, Mcmurray RW. Polymyositis, pulmonary fibrosis, and hepatitis C. Arthritis Rheum. 1995;38(3):437–9.

Masood M, Hamid S. Association of progression of pulmonary fibrosis in cirrhosis. Esculapio. 2011;7(1):12–4.

Ohta K, Ueda T, Nagai S, Yamada K, Yamaguchi M, Nakano J, et al. Pathogenesis of idiopathic pulmonary fibrosis–is hepatitis C virus involved? Nihon Kyobu Shikkan Gakkai Zasshi. 1993;31:32–5.

Irving WL, Day S, Johnston I. Virus Infertion. Am Rev Respir Dis. 1993;148:1683–4.

Meliconi R, Andreone P, Fasano L, Galli S, Pacilli A, Miniero R, et al. Incidence of hepatitis C virus infection in Italian patients with idiopathic pulmonary fibrosis. Thorax. 1996;51(3):315–7.

Ferri C, La Civita L, Fazzi P, Solfanelli S, Lombardini F, Begliomini E, et al. Interstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection. Br J Rheumatol. 1997;36(3):360–5.

Arase Y, Suzuki F, Suzuki Y, Akuta N, Kobayashi M, Kawamura Y, et al. Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis. World J Gastroenterol WJG. 2008;14(38):5880.

Abbas R, Massoud K, Hegazy AM, Shehata M. Risk of Pulmonary Fibrosis in Egyptian Patients with Chronic Hepatitis-C-Infection. Int J Intern Med. 2015;4(1):1–8.

Okanoue T, Sakamoto S, Itoh Y, Minami M, Yasui K, Sakamoto M, et al. Side effects of high-dose interferon therapy for chronic hepatitis C. J Hepatol. 1996;25(3):283–91.

Karino Y, Hige S, Matsushima T, Toyota J. Interstitial pneumonia induced by interferon therapy in type C hepatitis. Nihon Rinsho. 1994;52(7):1905–9.20.

Bombardieri S, Paoletti P, Ferri C, Di Munno O, Fornai E, Giuntini C. Lung involvement in essential mixed cryoglobulinemia. Am J Med. 1979;66(5):748–56.

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Published

2021-03-10

How to Cite

Hamid, shahid, Mehmood Khan, K., Ahmed, F. ., & Firdous, A. (2021). Frequency of restrictive pulmonary function tests in patients with chronic Hepatitis C. Pakistan Journal of Surgery and Medicine, 1(4), e223. https://doi.org/10.37978/pjsm.v1i4.223