Frequency of restrictive pulmonary function tests in patients with chronic Hepatitis C


  • shahid Hamid Dubai hospital , alhameed medical center
  • Khalid Medicine, King Edward Medical University Lahore
  • fawad Medicine, King Edward Medical University Lahore
  • Asia Firdous King Edward Medical University Lahore



Liver Cirrhosis, Pulmonary fibrosis, Respiratory Function Tests, Hepatitis C


Hepatis C infection is a common health problem world wide and is the major cause of chronic liver disease in Pakistan. Common complications of chronic hepatitis c infection are cirrhosis, ascities and hepatocellular carcinoma. Also HCV infection is associated with several extra hepatic manifestations including interstitial lung fibrosis. It has been found that frequency of pulmonary fibrosis is increased in patients with cirrhosis of liver as the stage of cirrhosis advances.This lung fibrosis can cause restrictive pattern of pulmonary function tests. This study was conducted to determine frequency of restrictive pulmonary function in patients with different stages of chronic hepatitis C  infection, based on child pough classification.

Study design

This is descriptive case study


99 patients of age range 20 to 80 year, both males and females having chronic hepatitis C infection and interferon based treatment naïve patients were included from outpatient and inpatient department were selected. Patients were divided into three groups according to child’s criteria i.e. group A, group B, and group C. Pulmonary function tests were performed on patients in all three groups to look for  FEV1/FVC ratio in all patients. FEV1/FVC ratio  more than 80 was considered as restrictive pulmonary function.


Out of 99 patients 32(35%) were found to have restrictive pattern of pulmonary functions


Chronic hepatitis C infection is associated with restrictive pattern of pulmonary function, suggestive of pulmonary fibrosis.


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How to Cite

Hamid, shahid, Mehmood Khan, K., Ahmed, F. ., & Firdous, A. (2021). Frequency of restrictive pulmonary function tests in patients with chronic Hepatitis C. Pakistan Journal of Surgery and Medicine, 1(4), e223.